Cindy Sember took top spot in the 100m hurdles while Britain’s men won the 4x100m relay, setting a world lead time in the process.
The women’s team came home second in their race, a finishing position matched by Jodie Williams in both the 200m and 400m, while Holly Bradshaw was runner-up in the pole vault.
Andrew Butchart came home third in the 3000m, as did Andrew Pozzi in the 110m hurdles, with CJ Ujah and Zharnel Hughes finishing second and third respectively across 100m.
Katarina Johnson-Thompson also continued her recovery from an Achilles injury by taking part in the long jump in front of home fans in the north east.
Sember must be wishing she can compete in Gateshead every week, with this her second victory of the season at the venue.
A time of 12.69 seconds marked an impressive outing for the 26-year-old, who finished just one place shy of winning an Olympic medal on her Games debut at Rio 2016.
“I’m so happy that the conditions held up and I’m just really happy to execute the performance today,” she said.
“I had an iffy British trials so I’m pleased to come back and show what I’m capable of doing and I’m happy with it.
“I just know that I’m in really good shape. I can do pretty good things so I’m excited.”